最近５年間(2010年～現在)の主な研究業績

「*」印はCorresponding author

２０１４年

1 *Mizushina, Y., Shiomi, K., Onodera, T., Kuriyama, I. (2014) Inhibitory effects of apigenin on mammalian DNA polymerase and proliferation of human cancer cells.
Apigenin: Natural Sources, Pharmacology and Role in Cancer Prevention, in press.

2 *Mizushina, Y., Kuriyama, I., Yoshida, H. (2014) Antimicrobial properties of Japanese wood essential oils against microorganisms related to food decay.
Essential Oils in Food Preservation, Flavour and Safety, in press.

3 Takemoto, K., *Kamisuki, S., Chia, P.T., Kuriyama, I., Mizushina, Y., Sugawara, F. (2014) Bioactive dihydronaphthoquinone derivatives from Fusarium solani.
Journal of Natural Products, 77, 1992-1996.

4 *Matsui, M., Iijima, H., Kiyozumi, Y., Mizushina, Y., Sakaguchi, K., Mizukami, F. (2014) The protein recognition ability of zeolites: complete separation of cytochrome c from a ternary protein mixture by zeolite L.
Analytical Methods, 6, 3569-3572.

5 *Mizushina, Y., Ogawa, Y., Onodera, T., Kuriyama, I., Sakamoto, Y., Nishikori, S., Kamisuki, S., Sugawara, F. (2014) Inhibition of mammalian DNA polymerases and the suppression of inflammatory and allergic responses by tyrosol from used activated charcoal waste generated during sake production.
Journal of Agricultural and Food Chemistry, 62, 7779-7786.

6 *Mizushina, Y., Onodera, T., Kuriyama, I., Nakayama, H., Sugimoto, K., Lee, E. (2014) Screening of mammalian DNA polymerase inhibitors from rosemary leaves and analysis of the anti-inflammatory and antiallergic effects of the isolated compounds.
Food Science and Technology Research, 20, 829-840.

7 Le, D.H., Takenaka, Y., Hamada, N., Mizushina, Y., *Tanahashi, T. (2014) Polyketides from the cultured lichen mycobiont of a vietnamese Pyrenula sp.
Journal of Natural Products, 77, 1402-1412.

8 Myobatake, Y., Takemoto, K., Kamisuki, S., Inoue, N., Takasaki, A., Takeuchi, T., Mizushina, Y., *Sugawara, F. (2014) Cytotoxic alkylated hydroquinone, phenol and cyclohexenone derivatives from Aspergillus violaceofuscus Gasperini.
Journal of Natural Products, 77, 1236-1240.

9 Mitoshi, M., Kuriyama, I., Nakayama, H., Miyazato, H., Sugimoto, K., Kobayashi, Y., Jippo, K., Kuramochi, K., Yoshida, H., *Mizushina, Y. (2014) Suppression of allergic and inflammatory responses by essential oils derived from herbal plants and citrus fruits.
International Journal of Molecular Medicine, 33, 1643-1651.

10 *Mizushina, Y., *Kuriyama, I., Yoshida, H. (2014) Inhibition of DNA polymerase λ and associated inflammatory activities of extracts from steamed germinated soybeans.
Food & Fuction, 5, 696-704.

11 Kozaki, S., Takenaka, Y., Mizushina, Y., Yamaura, T., *Tanahashi, T. (2014) Three acetophenones from Acronychia pedunculata.
Journal of Natural Medicines, 68, 421-426.

12 *Yoshida, H., Yoshida, N., Kuriyama, I., Kanamori, M., Sakamoto, Y., Mizushina, Y. (2014) Characteristics of fatty acid composition in different acyl lipids of colored rice bran cultivars.
Food Science and Technology Research, 20, 121-127.

13 Kawamura, M., Kuriyama, I., Maruo, S., *Kuramochi, K., Tsubaki, K., Yoshida, H., *Mizushina, Y. (2014) Anti-tumor effects of novel 5-O-acyl plumbagins based on the inhibition of mammalian DNA replicative polymerase activity.
Plos One, 9, e88736 (14 pages).

14 *Mizushina, Y., Fukudome, H.S., Takeuchi, T., Takemoto, K., Kuriyama, I., Yoshida, H., Kamisuki, S., Sugawara, F. (2014) Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus, Paecilomyces formosus.
Bioorganic and Medicinal Chemistry, 22, 1070-1076.

２０１３年

1 Kuriyama, I., Takahashi, Y., Yoshida, H., *Mizushina, Y. (2013) Inhibitory effect of isoflavones from processed soybeans on human DNA topoisomerase II activity.
Journal of Plant Biochemistry & Physiology, 1, 1000106 (3 pages).

2 Akasaka, H., Sasaki, R., Mukumoto, N., Nakayama, M., Miyawaki, D., Yoshida, K., Ejima, Y., Sulaiman, N.S., *Mizushina, Y. (2013) A novel radiosensitizer of the functional food component, monogalactosyl diacylglycerol (MGDG) from spinach, enhanced the cytotoxic effects for the pancreatic cancer in vitro and in vivo.
International Journal of Radiation Oncology Biology Physics, 87, S636.

3 *Yoshida, H., Kanamori, M., Yoshida, N., Sakamoto, Y., Kuriyama, I., Mizushina, Y. (2013) Vitamin E profiles and triacylglycerol molecular species of colored rice bran cultivars at different degree of milling.
Journal of Food Research, 2, 106-116.

4 *Yoshida, H., Yoshida, N., Sakamoto, Y., Kuriyama, I., Mizushina, Y. (2013) Tocopherol distributions and regiospecific profiles of fatty acids of Jack beans (Canavalia gladiata DC.).
Canadian Journal of Plant Breeding, 1, 51-59.

5 Ou, J.L., Mizushina, Y., Wang, S.Y., Chuang, D.Y., Nadar, M., *Hsu, W.L. (2013) Structure-activity relationship analysis of curcumin analogues on anti-influenza virus activity.
FEBS Journal, 280, 5829-5840.

6 *Kuramochi, K., Tsubaki, K., Kuriyamai, I., Mizushina, Y., Yoshida, H., Takeuchi, T., Kamisuki, S., Sugawara, F., Kobayashi, S. (2013) Synthesis, structure and cytotoxicity studies of some fungal isochromanes.
Journal of Natural Products, 76, 1737-1745.

7 *Mizushina, Y., Kuriyama, I., Takeuchi, T., Sugawara, F., Yoshida, H. (2013) Effects of carotenoids on mammalian DNA polymerase inhibition and anti-inflammation.
Carotenoids: Food Sources, Production and Health Benefits, 15, 297-318.

8 *Mizushina, Y., Kuriyama, I., Nakahara, T., Kawashima, Y., Yoshida, H. (2013) Inhibitory effects of α-mangostin on mammalian DNA polymerase, topoisomerase, and human cancer cell proliferation.
Food and Chemical Toxicology, 59, 793-800.

9 *Mizushina, Y., Shiomi K., Kuriyama, I., Takahashi, Y., Yoshida, H. (2013) Inhibitory effects of a major soy isoflavone, genistein, on human DNA topoisomerase II activity and cancer cell proliferation.
International Journal of Oncology, 43, 1117-1124.

10 Kuriyama, I., Nakajima, Y., Nishida, H., Konishi, T., Takeuchi, T., Sugawara, F., Yoshida, H., *Mizushina, Y. (2013) Inhibitory effects of low-molecular-weight polyphenolics from Inonotus obliquus on human DNA topoisomerase activity and cancer cell proliferation.
Molecular Medicine Reports, 8, 535-542.

11 *Mizushina, Y., Takahashi, Y., Kuriyama, I., Yoshida, H. (2013) Anti-inflammatory effect of the waste components from soybean (Glycine max L.) oil based on DNA polymerase λ inhibition.
Agricultural Research Updates. Volume 5, 3, 63-84.

12 *Mizushina, Y., Kuriyama, I., Yamazaki, A., Akashi, T., Yoshida, H. (2013) Cycloartenyl trans-ferulate, a component of the bran byproduct of sake-brewing rice, inhibits mammalian DNA polymerase and suppresses inflammation.
Food Chemistry, 141, 1000-1007.

13 Shiomi, K., Kuriyama, I., Yoshida, H., *Mizushina, Y. (2013) Inhibitory effects of myricetin on mammalian DNA polymerase, topoisomerase and human cancer cell proliferation.
Food Chemistry, 139, 910-918.

14 *Mizushina, Y., Nishiumi, S., Nishida, M., Yoshida, H., Azuma, T., Yoshida, M. (2013) Inhibition of repair-related DNA polymerases by vitamin Ks, their related quinone derivatives and associated inflammatory activity.
International Journal of Oncology, 42, 793-802.

15 Akasaka, H., Sasaki, R., Yoshida, K., Takayama, I., Yamaguchi, T., Yoshida, H., *Mizushina, Y. (2013) Monogalactosyl diacylglycerol, a replicative DNA polymerase inhibitor, from spinach enhances the anti-cell proliferation effect of gemcitabine in human pancreatic cancer cells.
Biochimica et Biophysica Acta, 1830, 2517-2525.

16 Yoshida, N., Kuriyama, I., Yoshida, H., *Mizushina, Y. (2013) Inhibitory effects of catechin derivatives on mammalian DNA polymerase and topoisomerase activities and mouse one-cell zygote development.
Journal of Bioscience and Bioengineering, 115, 303-309.

17 Kuriyama, I., *Miyazaki, A., Tsuda, Y., Yoshida, H., *Mizushina, Y. (2013) Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymerase β.
Bioorganic and Medicinal Chemistry, 21, 403-411.

18 *Yoshida, H., Yoshida, N., Kuriyama, I., Sakamoto, Y.T., Mizushina, Y. (2013) Profiles of lipid components, fatty acid distributions of triacylglycerols and phospholipids in Jack beans (Canavalia gladiata DC.).
Food Chemistry, 136, 807-812.

19 Maeda, N., Yasuo, K., Hada, T., Yoshida, H., *Mizushina, Y. (2013) Oral administration of monogalactocyl diacylglycerol from spinach inhibits colon tumor growth in mice.
Experimental and Therapeutic Medicine, 5, 17-22.

20 *Mizushina, Y., Sakaguchi, K., Sugawara, F., Yoshida, H. (2013) Inhibitory mechanism of longer chain fatty acids on mammalian DNA polymerase β activity.
Biochemistry Researcher Biographical Sketches and Research Summaries, 355-356.

２０１２年

1 *Yoshida, H., Sakamoto, Y.T., Mizushina, Y., Yoshida, N. (2012) Profiles of fatty acid distribution of different acyl lipids from red and black rices.
Journal of Food Research, 1, 46-53.

2 *Yoshida, H., Yoshida, N., Sakamoto, Y.T., Mizushina, Y. (2012) Caracteristics of lipid components and triacyl glycerol molecular species of jack bean (Canavalia gladiata DC.).
Food Science and Technology Research, 18, 893-900.

3 *Mizushina, Y., Kuriyama, I., Yoshida, H. (2012) Novel compounds from marine microorganisms that inhibit mammalian DNA polymerase.
Current Organic Chemistry, 16, 2961-2969.

4 Mitoshi, M., Kuriyama, I., Nakayama, H., Miyazato, H., Sugimoto, K., Kobayashi, Y., Jippo, T., Kanazawa, K., Yoshida, H., *Mizushina, Y. (2012) Effects of essential oils from herbal plants and citrus fruits on DNA polymerase inhibitory, cancer cell growth inhibitory, antiallergic, and antioxidant activities.
Journal of Agricultural and Food Chemistry, 60, 11343-11350.

5 *Mizushina, Y., Yonezawa, Y.K., Yoshida, H. (2012) Enhancement of human cancer cell radiosensitivity by conjugated eicosapentaenoic acid, an inhibitor of DNA polymerase and topoisomerase.
Horizons in Cancer Research, 5, 89-109.

6 *Mizushina, Y., Takeuchi, T., Sugawara, F., Yoshida, H. (2012) Anti-cancer targeting telomerase inhibitors: β-rubromycin and oleic acid.
Mini-Reviews in Medicinal Chemistry, 12, 1135-1143.

7 Takeuchi, T., Mizushina, Y., Takaichi, S., Inoue, N., Kuramochi, K., Shimura, S., Myobatake, Y., Katayama, Y., Takemoto, K., Kamisuki, S., *Sugawara, F. (2012) Oral administration of monogalactocyl diacylglycerol from spinach inhibits colon tumor growth in mice.
Organic Letters, 14, 4303-4307.

8 *Yoshida, H., Yoshida, N., Tomiyama-Sakamoto, Y., Mizushina, Y. (2012) Characteristic distributions of fatty acids in different lipids from Jack beans (Canavalia gladiata DC.).
European Journal of Lipid Science and Technology, 114, 787-793.

9 Ishida, T., *Mizushina, Y., Yagi, S., Irino, Y., Nishiumi, S., Miki, I., Kondo, Y., Mizuno, S., Yoshida, H., Azuma, T., *Yoshida, M. (2012) Inhibitory effects of glycyrrhetinic acid on DNA polymerase and inflammatory activities.
Evidence-based Complementary and Alternative Medicine, 2012, Article ID: 650514 (9 pages).

10 *Mizushina, Y., Hada, T., Yoshida, H. (2012) In vivo antitumor effect of liposomes with sialyl Lewis X including monogalactosyl diacylglycerols, a replicative DNA polymerase inhibitor, from spinach.
Oncology Reports, 28, 821-828.

11 Miyano, Y., Tsukuda, S., Sakimoto, I., Takeuchi, R., Shimura, S., Takahashi, N., Kusayanagi, T., Takakusagi, Y., Okado, M., Matsumoto, Y., Takakusagi, K., Takeuchi, T., Kamisuki, S., Nakazaki, A., Ohta, K., Miura, M., *Kuramochi, K., Mizushina, Y., Kobayashi, S., Sugawara, F., Sakaguchi, K. (2012) Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen.
Bioorganic and Medicinal Chemistry, 20, 3985-3990.

12 *Yoshida, H., Kuriyama, I., Sakamoto, Y.T., Mizushina, Y. (2012) Profiles of lipid components, fatty acid compositions and triacylglycerol molecular species in the lipids from rice beans.
Food Science and Technology Research, 18, 219-226.

13 Takao, Y., Kuriyama, I., Yamada, T., Mizoguchi, H., Yoshida, H., *Mizushina, Y. (2012) Antifungal properties of Japanese cedar essential oil from waste wood chips made from used sake barrels.
Molecular Medicine Reports, 5, 1163-1168.

14 Myobatake, Y., Takeuchi, T., Kuramochi, K., Kuriyama, I., Ishido, T., Hirano, K., Sugawara, F., Yoshida, H., *Mizushina, Y. (2012) Pinophilins A and B, inhibitors of mammalian A-, B- and Y-families of DNA polymerases and human cancer cell proliferation.
Journal of Natural Products, 75, 135-141.

15 Mizuno, T., Kuriyama, I., Takemura, M., Sakaguchi, K., Sugawara, F., Yoshida, H., *Mizushina, Y. (2012) Effect of a specific mammalian DNA polymerase α inhibitor, dehydroaltenusin, on DNA replication in cultured cells.
DNA Replication and Mutation, 4, 67-90.

16 *Mizushina, Y., Takahashi, Y., Sato, Y., Yamaguchi, Y., Takeuchi, T., Kuriyama, I., Sugawara, F., Yoshida, H. (2012) Inhibition of DNA polymerase λ by glucosyl compounds from soybean (Glycine max L.) and their associated inflammatory activity.
Food Chemistry, 132, 2046-2053.

２０１１年

1 *Mizushina, Y., Nishida, M., Azuma, T., *Yoshida, M. (2011) Inhibition of DNA polymerase λ, a DNA repair enzyme, and anti-inflammation: chemical knocked out analysis for DNA polymerase λ by curcumin derivatives.
DNA Repair and Human Health, 31, 777-792.

2 *Mizushina, Y., Maeda, N., Kuriyama, I., Yoshida, H. (2011) Dehydroaltenusin is a specific inhibitor of mammalian DNA polymerase α.
Expert Opinion on Investigational Drugs, 20, 1523-1534.

3 Aoganghua, A., Nishiumi, S., Kobayashi, K., Nishida, M., Kuramochi, K., Tsubaki, K., Hirai, M., Tanaka, S., Azuma, T., Yoshida, H., *Mizushina, Y., *Yoshida, M. (2011) Inhibitory effects of vitamin K3 derivatives on DNA polymerase and inflammatory activities.
International Journal of Molecular Medicine, 28, 937-945.

4 Maruo, S., Kuriyama, I., *Kuramochi, K., Tsubaki, K., Yoshida, H., *Mizushina, Y. (2011) Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response.
Bioorganic and Medicinal Chemistry, 19, 5803-5812.

5 *Mizushina, Y., Takeuchi, T., Kuriyama, I., Takahashi, Y., Maezawa, S., Matsumoto, T., Koiwai, O., Sugawara, F., Yoshida, H. (2011) DNA polymerase β specific inhibitors, a loliolide derivative and pubinernoid A, isolated from the brown algae Laminaria sp..
Letters in Drug Design and Discovery, 8, 671-677.

6 *Takemura, M., Kazama, T., Sakuma, K., Mizushina, Y., Oshima, T (2011) Growth inhibition and chromosomal instability of cultured marsupial (opossum) cells after treatment with DNA polymerase α inhibitor.
Bioscience Biotechnology and Biochemistry, 75, 1349-1353.

7 *Kuramochi, K., Sunoki, T., Tsubaki, K., Mizushina, Y., Sakaguchi, K., Sugawara, F., Ikekita, M., Kobayashi, S. (2011) Transformation of thiols to disulfides by epolactaene and its derivatives.
Bioorganic and Medicinal Chemistry, 19, 4162-4172.

8 *Yoshida, H., Tanigawa, T., Yoshida, N., Kuriyama, I., Tomiyama, Y., Mizushina, Y. (2011) Lipid components, fatty acid distributions of triacylglycerols and phospholipids in rice brans.
Food Chemistry, 129, 479-484.

9 *Mizushina, Y., Saito, A., Horikawa, K., Nakajima, N., Tanaka, A., Yoshida, H., Matsubara, K. (2011) Acylated catechin derivatives: inhibitors of DNA polymerase and angiogenesis.
Frontiers in Bioscience, E3, 1337-1348.

10 *Yoshida, H., Tanigawa, T., Kuriyama, I., Yoshida, N., Tomiyama, Y., Mizushina, Y. (2011) Variation in fatty acid distribution of different acyl lipids in rice (Oryza sativa L.) brans.
Nutrients, 3, 505-514.

11 Yim, M.J., *Hosokawa, M., Mizushina, Y., Yoshida, H., Saito, Y., Miyashita, K. (2011) Suppressive effects of amarouciaxanthin A on 3T3-L1 adipocyte differentiation through down-regulation of PPARγ and C/EBPα mRNA expression.
Journal of Agricultural and Food Chemistry, 59, 1646-1652.

12 *Mizushina, Y., Maeda, J., Irino, Y., Nishida, M., Nishiumi, S., Kondo, Y., Nishio, K., Kuramochi, K., Tsubaki, K., Kuriyama, I., Azuma, T., *Yoshida, H., Yoshida, M. (2011) Effects of intermediates between vitamins K2 and K3 on mammalian DNA polymerase inhibition and anti-inflammatory activity.
International Journal of Molecular Sciences, 12, 1115-1132.

13 Kuramochi, K., Kuriyama, I., Mori, M., Kamisuki, S., Takahashi, S., Tsubaki, K., Sugawara, F., Sakaguchi, K., Yoshida, H., *Mizushina, Y. (2011) Syntheses of dehydroaltenusin, a selective inhibitor of mammalian DNA polymerase α.
Current Organic Synthesis, 8, 134-144.

14 *Yoshida, H., Yoshida, N., Tomiyama, Y., Mizushina, Y. (2011) Composition and regiodistribution of fatty acids in triacylglycerols and phospholipids from red and black rices.
Cereal Chemistry, 88, 31-35.

15 Kobayashi, K., Nishiumi, S., Nishida, M., Hirai, M., Azuma, T., Yoshida, H., *Mizushina, Y., *Yoshida, M. (2011) Effects of quinone derivatives, such as 1,4-naphthoquinone, on DNA polymerase inhibition and anti-inflammatory action.
Medicinal Chemistry, 7, 37-44.

16 Maeda, N., Matsubara, K., Yoshida, H., *Mizushina, Y. (2011) Anti-cancer effect of spinach glycoglycerolipids as angiogenesis inhibitors based on the selective inhibition of DNA polymerase activity.
Mini-Reviews in Medicinal Chemistry, 11, 32-38.

17 Okusada, K., Nakamoto, K., Nishida, M., Hamabe, W.F., Kamiya, K., Mizushina, Y., Satake, T., *Tokuyama, S. (2011) The antinociceptive and anti-inflammatory action of the CHCl3-soluble phase and its main active component, damnacanthal, isolated from the root of Morinda citrifolia.
Biological & Pharmaceutical Bulletin, 34, 103-107.

２０１０年

1 Kuriyama, I., Miyazaki, A., Tsuda, Y., Yokoi, T., Okada, Y., Takeuchi, T., Sugawara, F., Yoshida, H., *Mizushina, Y. (2010) Inhibitory effect of somatostatin peptide analogues on DNA polymerase activity and human cancer cell proliferation.
Anticancer Research, 30, 4841-4849.

2 *Yoshida, H., Tomiyama, Y., Mizushina, Y. (2010) Tocopherol distributions and triacylglycerol molecular species in broad beans (Vicia Faba).
Food Science and Technology Research, 16, 409-416.

3 Horie, S., Okuda, C., Yamashita, T., Watanabe, K., Yamaguchi, Y., Takeuchi, T., Sugawara, F., Yoshida, H., *Mizushina, Y. (2010) β-Sitosteryl (6’-O-linoleoyl)-glucoside of soybean (Glycine max L.) crude extract inhibits Y-family DNA polymerases.
Journal of Oleo Science, 59, 621-630.

4 Amalia, H., *Sasaki, R., Suzuki, Y., Demizu, Y., Bito, T., Nishimura, H., Okamoto, Y., Yoshida, K., Miyawaki, D., Kawabe, T., Mizushina, Y., Sugimura, K. (2010) Vitamin K2 derived compounds induce growth inhibition in radioresistant cancer cells.
Kobe Journal of Medical Sciences, 56, E38-E49.

5 Maeda, J., Nishida, M., Takikawa, H., Yoshida, H., Azuma, T., *Yoshida, M., *Mizushina, Y. (2010) Inhibitory effects of sulfobacin B on DNA polymerase and inflammation.
International Journal of Molecular Medicine, 26, 751-758.

6 Harada, S., Fujita-Hamabe, W., Kamiya, K., Mizushina, Y., Satake, T., *Tokuyama, S. (2010) Morinda citrifolia fruit juice prevents ischemic neuronal damage through suppression of the development of post-ischemic glucose intolerance.
Journal of Natural Medicines, 64, 468-473.

7 *Mizushina, Y., Zhang, J., Pugliese, A., Kim, S.H., *Lü, J. (2010) Anti-cancer gallotannin penta-O-galloyl-beta-D-glucose is a nanomolar inhibitor of select mammalian DNA polymerases.
Biochemical Pharmacology, 80, 1125-1132.

8 *Mizushina, Y., Nishimura, N., Takenaka, Y., Takeuchi, T., Sugawara, F., Yoshida, H., Tanahashi, T. (2010) Inhibitory effects of docosyl p-coumarate on DNA topoisomerase activity and human cancer cell growth.
International Journal of Oncology, 37, 933-1000.

9 Kayashima, T., Mori, M., Mizutani, R., Nishino, K., Kuramochi, K., Tsubaki, K., Yoshida, H., Mizushina, Y., *Matsubara, K. (2010) Synthesis and biological evaluation of vitamin K derivatives as angiogenesis inhibitor.
Bioorganic and Medicinal Chemistry, 18, 6305-6309.

10 Horie, S., Okuda, C., Yamashida, T., Watanabe, K., Kuramochi, K., Hosokawa, M., Takeuchi, T., Kakuda, M., Miyashida, K., Sugawara, F., Yoshida, H., *Mizushina, Y. (2010) Purified canola lutein selectively inhibits specific isoforms of mammalian DNA polymerases and reduces inflammatory response.
Lipids, 45, 713-721.

11 *Hirano, K., Yoshida, Y., Ishidoh, T., Wada, Y., Moriya, N., Yamazaki, N., Mizushina, Y., Baba, Y., Ishikawa, M. (2010) Consecutive incorporation of fluorophore-labelled nucleotides by mammalian DNA polymerase β.
Analytical Biochemistry, 405, 160-167.

12 Ishimaru, C., Takeuchi, T., Sugawara, F., Yoshida, H., *Mizushina, Y. (2010) Inhibitory effects of diacylglyceride phospholipids on DNA polymerase and topoisomerase activities, and human cancer cell growth.
Medicinal Chemistry, 6, 114-122.

13 *Mizushina, Y., Sakaguchi, K., Sugawara, F., Yoshida, H. (2010) Inhibitory mechanism of longer chain fatty acids on mammalian DNA polymerase beta activity.
Handbook of Nutritional Biochemistry: Genomics, Metabolomics and Food Supply, 445-463.

14 *Yoshida, H., Yoshida, N., Tomiyama, Y., Mizushina, Y. (2010) Fatty acid characteristics of triacylglycerols and phospholipids of azuki beans (Vigna angularis).
Food Science and Technology Research, 16, 209-214.

15 *Yoshida, H., Tomiyama, Y., Mizushina, Y. (2010) Lipids components, fatty acids and triacylglycerol molecular species of black and red rices.
Food Chemistry, 123, 210-215.

16 Yamaguchi, Y., Manita, D., Takeuchi, T., Kuramochi, K., Kuriyama, I., Sugawara, F., Yoshida, H., *Mizushina, Y. (2010) Novel terpenoids, trichoderonic acids A and B isolated from Trichoderma virens, are selective inhibitors of family X DNA polymerases.
Bioscience Biotechnology and Biochemistry, 74, 793-801.

17 Tanaka, S., Nishiumi, S., Nishida, M., Mizushina, Y., Kobayashi, K., Masuda, A., Fujita, T., Morita, Y., Mizuno, S., Kutsumi, H., T.Azuma, T., *Yoshida, M. (2010) Vitamin K3 attenuates lipopolysaccharide-induced acute lung injury through inhibition of nuclear factor-κB activation.
Clinical and Experimental Immunology, 160, 283-292.

18 Nishida, M., Nishiumi, S., Mizushina, Y., Fujishima, Y., Yamamoto, K., Masuda, A., Mizuno, S., Fujita, T., Morita, Y., Kutsumi, H., Yoshida, H., Azuma, T., *Yoshida, M. (2010) Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation.
International Journal of Molecular Medicine, 25, 761-767.

19 Yonezawa, Y.K., Sasaki, R., Suzuki, Y., Matsui, Y., Hada, T., Uryu, K., Sugimura, K., Yoshida, H., *Mizushina, Y. (2010) Enhancement of human cancer cell radiosensitivity by conjugated eicosapentaenoic acid - a mammalian DNA polymerase inhibitor.
International Journal of Oncology, 36, 577-584.

20 *Yoshida, H., Tomiyama, Y., Yoshida, N., Shibata, K., Mizushina, Y. (2010) Regiospecific profiles of fatty acids in triacylglycerols and phospholipids from adzuki beans (Vigna angularis).
Nutrients, 2, 49-59.

21 Kamiya, K., Hamabe, W., Tokuyama, S., Hirano, K., Satake, T., Yonezawa, Y.K., Yoshida, H., *Mizushina, Y. (2010) Inhibitory effect of anthraquinones isolated from the root of Noni (Morinda citrifolia) on animal A, B and Y families of DNA polymerases and human cancer cell proliferation.
Food Chemistry, 118, 725-730.

22 Matsui Y., Takeuchi, T., Yonezawa, Y.K., Takemura, M., Sugawara, F., Yoshida, H., *Mizushina, Y. (2010) The relationship between the molecular structure of natural acetogenins and their inhibitory activities which affect DNA polymerase, DNA topoisomerase and human cancer cell growth.
Experimental and Therapeutic Medicine, 1, 19-26.

23 Maeda, N., Yoshida, H., *Mizushina, Y. (2010) Spinach and health: Anti-cancer effect.
Bioactive Foods in Promoting Health: Fruits and Vegetables, Chapter 26, 393-405.

1	Mizushina, Y., Shiomi, K., Onodera, T., Kuriyama, I. (2014) Inhibitory effects of apigenin on mammalian DNA polymerase and proliferation of human cancer cells. Apigenin: Natural Sources, Pharmacology and Role in Cancer Prevention*, in press.
2	Mizushina, Y., Kuriyama, I., Yoshida, H. (2014) Antimicrobial properties of Japanese wood essential oils against microorganisms related to food decay. Essential Oils in Food Preservation, Flavour and Safety*, in press.
3	Takemoto, K., Kamisuki, S., Chia, P.T., Kuriyama, I., Mizushina, Y., Sugawara, F. (2014) Bioactive dihydronaphthoquinone derivatives from Fusarium solani. Journal of Natural Products*, 77, 1992-1996.
4	Matsui, M., Iijima, H., Kiyozumi, Y., Mizushina, Y., Sakaguchi, K., Mizukami, F. (2014) The protein recognition ability of zeolites: complete separation of cytochrome c from a ternary protein mixture by zeolite L. Analytical Methods*, 6, 3569-3572.
5	Mizushina, Y., Ogawa, Y., Onodera, T., Kuriyama, I., Sakamoto, Y., Nishikori, S., Kamisuki, S., Sugawara, F. (2014) Inhibition of mammalian DNA polymerases and the suppression of inflammatory and allergic responses by tyrosol from used activated charcoal waste generated during sake production. Journal of Agricultural and Food Chemistry*, 62, 7779-7786.
6	Mizushina, Y., Onodera, T., Kuriyama, I., Nakayama, H., Sugimoto, K., Lee, E. (2014) Screening of mammalian DNA polymerase inhibitors from rosemary leaves and analysis of the anti-inflammatory and antiallergic effects of the isolated compounds. Food Science and Technology Research*, 20, 829-840.
7	Le, D.H., Takenaka, Y., Hamada, N., Mizushina, Y., Tanahashi, T. (2014) Polyketides from the cultured lichen mycobiont of a vietnamese Pyrenula sp. Journal of Natural Products*, 77, 1402-1412.
8	Myobatake, Y., Takemoto, K., Kamisuki, S., Inoue, N., Takasaki, A., Takeuchi, T., Mizushina, Y., Sugawara, F. (2014) Cytotoxic alkylated hydroquinone, phenol and cyclohexenone derivatives from Aspergillus violaceofuscus Gasperini. Journal of Natural Products*, 77, 1236-1240.
9	Mitoshi, M., Kuriyama, I., Nakayama, H., Miyazato, H., Sugimoto, K., Kobayashi, Y., Jippo, K., Kuramochi, K., Yoshida, H., Mizushina, Y. (2014) Suppression of allergic and inflammatory responses by essential oils derived from herbal plants and citrus fruits. International Journal of Molecular Medicine*, 33, 1643-1651.
10	Mizushina, Y., Kuriyama, I., Yoshida, H. (2014) Inhibition of DNA polymerase λ and associated inflammatory activities of extracts from steamed germinated soybeans. Food & Fuction, 5, 696-704.
11	Kozaki, S., Takenaka, Y., Mizushina, Y., Yamaura, T., Tanahashi, T. (2014) Three acetophenones from Acronychia pedunculata. Journal of Natural Medicines*, 68, 421-426.
12	Yoshida, H., Yoshida, N., Kuriyama, I., Kanamori, M., Sakamoto, Y., Mizushina, Y. (2014) Characteristics of fatty acid composition in different acyl lipids of colored rice bran cultivars. Food Science and Technology Research*, 20, 121-127.
13	Kawamura, M., Kuriyama, I., Maruo, S., Kuramochi, K., Tsubaki, K., Yoshida, H., Mizushina, Y. (2014) Anti-tumor effects of novel 5-O-acyl plumbagins based on the inhibition of mammalian DNA replicative polymerase activity. Plos One, 9, e88736 (14 pages).
14	Mizushina, Y., Fukudome, H.S., Takeuchi, T., Takemoto, K., Kuriyama, I., Yoshida, H., Kamisuki, S., Sugawara, F. (2014) Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus, Paecilomyces formosus. Bioorganic and Medicinal Chemistry*, 22, 1070-1076.

1	Kuriyama, I., Takahashi, Y., Yoshida, H., Mizushina, Y. (2013) Inhibitory effect of isoflavones from processed soybeans on human DNA topoisomerase II activity. Journal of Plant Biochemistry & Physiology*, 1, 1000106 (3 pages).
2	Akasaka, H., Sasaki, R., Mukumoto, N., Nakayama, M., Miyawaki, D., Yoshida, K., Ejima, Y., Sulaiman, N.S., Mizushina, Y. (2013) A novel radiosensitizer of the functional food component, monogalactosyl diacylglycerol (MGDG) from spinach, enhanced the cytotoxic effects for the pancreatic cancer in vitro and in vivo. International Journal of Radiation Oncology Biology Physics*, 87, S636.
3	Yoshida, H., Kanamori, M., Yoshida, N., Sakamoto, Y., Kuriyama, I., Mizushina, Y. (2013) Vitamin E profiles and triacylglycerol molecular species of colored rice bran cultivars at different degree of milling. Journal of Food Research*, 2, 106-116.
4	Yoshida, H., Yoshida, N., Sakamoto, Y., Kuriyama, I., Mizushina, Y. (2013) Tocopherol distributions and regiospecific profiles of fatty acids of Jack beans (Canavalia gladiata DC.). Canadian Journal of Plant Breeding*, 1, 51-59.
5	Ou, J.L., Mizushina, Y., Wang, S.Y., Chuang, D.Y., Nadar, M., Hsu, W.L. (2013) Structure-activity relationship analysis of curcumin analogues on anti-influenza virus activity. FEBS Journal*, 280, 5829-5840.
6	Kuramochi, K., Tsubaki, K., Kuriyamai, I., Mizushina, Y., Yoshida, H., Takeuchi, T., Kamisuki, S., Sugawara, F., Kobayashi, S. (2013) Synthesis, structure and cytotoxicity studies of some fungal isochromanes. Journal of Natural Products*, 76, 1737-1745.
7	Mizushina, Y., Kuriyama, I., Takeuchi, T., Sugawara, F., Yoshida, H. (2013) Effects of carotenoids on mammalian DNA polymerase inhibition and anti-inflammation. Carotenoids: Food Sources, Production and Health Benefits*, 15, 297-318.
8	Mizushina, Y., Kuriyama, I., Nakahara, T., Kawashima, Y., Yoshida, H. (2013) Inhibitory effects of α-mangostin on mammalian DNA polymerase, topoisomerase, and human cancer cell proliferation. Food and Chemical Toxicology*, 59, 793-800.
9	Mizushina, Y., Shiomi K., Kuriyama, I., Takahashi, Y., Yoshida, H. (2013) Inhibitory effects of a major soy isoflavone, genistein, on human DNA topoisomerase II activity and cancer cell proliferation. International Journal of Oncology*, 43, 1117-1124.
10	Kuriyama, I., Nakajima, Y., Nishida, H., Konishi, T., Takeuchi, T., Sugawara, F., Yoshida, H., Mizushina, Y. (2013) Inhibitory effects of low-molecular-weight polyphenolics from Inonotus obliquus on human DNA topoisomerase activity and cancer cell proliferation. Molecular Medicine Reports*, 8, 535-542.
11	Mizushina, Y., Takahashi, Y., Kuriyama, I., Yoshida, H. (2013) Anti-inflammatory effect of the waste components from soybean (Glycine max L.) oil based on DNA polymerase λ inhibition. Agricultural Research Updates. Volume 5*, 3, 63-84.
12	Mizushina, Y., Kuriyama, I., Yamazaki, A., Akashi, T., Yoshida, H. (2013) Cycloartenyl trans-ferulate, a component of the bran byproduct of sake-brewing rice, inhibits mammalian DNA polymerase and suppresses inflammation. Food Chemistry*, 141, 1000-1007.
13	Shiomi, K., Kuriyama, I., Yoshida, H., Mizushina, Y. (2013) Inhibitory effects of myricetin on mammalian DNA polymerase, topoisomerase and human cancer cell proliferation. Food Chemistry*, 139, 910-918.
14	Mizushina, Y., Nishiumi, S., Nishida, M., Yoshida, H., Azuma, T., Yoshida, M. (2013) Inhibition of repair-related DNA polymerases by vitamin Ks, their related quinone derivatives and associated inflammatory activity. International Journal of Oncology*, 42, 793-802.
15	Akasaka, H., Sasaki, R., Yoshida, K., Takayama, I., Yamaguchi, T., Yoshida, H., Mizushina, Y. (2013) Monogalactosyl diacylglycerol, a replicative DNA polymerase inhibitor, from spinach enhances the anti-cell proliferation effect of gemcitabine in human pancreatic cancer cells. Biochimica et Biophysica Acta*, 1830, 2517-2525.
16	Yoshida, N., Kuriyama, I., Yoshida, H., Mizushina, Y. (2013) Inhibitory effects of catechin derivatives on mammalian DNA polymerase and topoisomerase activities and mouse one-cell zygote development. Journal of Bioscience and Bioengineering*, 115, 303-309.
17	Kuriyama, I., Miyazaki, A., Tsuda, Y., Yoshida, H., Mizushina, Y. (2013) Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymerase β. Bioorganic and Medicinal Chemistry, 21, 403-411.
18	Yoshida, H., Yoshida, N., Kuriyama, I., Sakamoto, Y.T., Mizushina, Y. (2013) Profiles of lipid components, fatty acid distributions of triacylglycerols and phospholipids in Jack beans (Canavalia gladiata DC.). Food Chemistry*, 136, 807-812.
19	Maeda, N., Yasuo, K., Hada, T., Yoshida, H., Mizushina, Y. (2013) Oral administration of monogalactocyl diacylglycerol from spinach inhibits colon tumor growth in mice. Experimental and Therapeutic Medicine*, 5, 17-22.
20	Mizushina, Y., Sakaguchi, K., Sugawara, F., Yoshida, H. (2013) Inhibitory mechanism of longer chain fatty acids on mammalian DNA polymerase β activity. Biochemistry Researcher Biographical Sketches and Research Summaries*, 355-356.

1	Yoshida, H., Sakamoto, Y.T., Mizushina, Y., Yoshida, N. (2012) Profiles of fatty acid distribution of different acyl lipids from red and black rices. Journal of Food Research*, 1, 46-53.
2	Yoshida, H., Yoshida, N., Sakamoto, Y.T., Mizushina, Y. (2012) Caracteristics of lipid components and triacyl glycerol molecular species of jack bean (Canavalia gladiata DC.). Food Science and Technology Research*, 18, 893-900.
3	Mizushina, Y., Kuriyama, I., Yoshida, H. (2012) Novel compounds from marine microorganisms that inhibit mammalian DNA polymerase. Current Organic Chemistry*, 16, 2961-2969.
4	Mitoshi, M., Kuriyama, I., Nakayama, H., Miyazato, H., Sugimoto, K., Kobayashi, Y., Jippo, T., Kanazawa, K., Yoshida, H., Mizushina, Y. (2012) Effects of essential oils from herbal plants and citrus fruits on DNA polymerase inhibitory, cancer cell growth inhibitory, antiallergic, and antioxidant activities. Journal of Agricultural and Food Chemistry*, 60, 11343-11350.
5	Mizushina, Y., Yonezawa, Y.K., Yoshida, H. (2012) Enhancement of human cancer cell radiosensitivity by conjugated eicosapentaenoic acid, an inhibitor of DNA polymerase and topoisomerase. Horizons in Cancer Research*, 5, 89-109.
6	Mizushina, Y., Takeuchi, T., Sugawara, F., Yoshida, H. (2012) Anti-cancer targeting telomerase inhibitors: β-rubromycin and oleic acid. Mini-Reviews in Medicinal Chemistry*, 12, 1135-1143.
7	Takeuchi, T., Mizushina, Y., Takaichi, S., Inoue, N., Kuramochi, K., Shimura, S., Myobatake, Y., Katayama, Y., Takemoto, K., Kamisuki, S., Sugawara, F. (2012) Oral administration of monogalactocyl diacylglycerol from spinach inhibits colon tumor growth in mice. Organic Letters*, 14, 4303-4307.
8	Yoshida, H., Yoshida, N., Tomiyama-Sakamoto, Y., Mizushina, Y. (2012) Characteristic distributions of fatty acids in different lipids from Jack beans (Canavalia gladiata DC.). European Journal of Lipid Science and Technology*, 114, 787-793.
9	Ishida, T., Mizushina, Y., Yagi, S., Irino, Y., Nishiumi, S., Miki, I., Kondo, Y., Mizuno, S., Yoshida, H., Azuma, T., Yoshida, M. (2012) Inhibitory effects of glycyrrhetinic acid on DNA polymerase and inflammatory activities. Evidence-based Complementary and Alternative Medicine, 2012, Article ID: 650514 (9 pages).
10	Mizushina, Y., Hada, T., Yoshida, H. (2012) In vivo antitumor effect of liposomes with sialyl Lewis X including monogalactosyl diacylglycerols, a replicative DNA polymerase inhibitor, from spinach. Oncology Reports*, 28, 821-828.
11	Miyano, Y., Tsukuda, S., Sakimoto, I., Takeuchi, R., Shimura, S., Takahashi, N., Kusayanagi, T., Takakusagi, Y., Okado, M., Matsumoto, Y., Takakusagi, K., Takeuchi, T., Kamisuki, S., Nakazaki, A., Ohta, K., Miura, M., Kuramochi, K., Mizushina, Y., Kobayashi, S., Sugawara, F., Sakaguchi, K. (2012) Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen. Bioorganic and Medicinal Chemistry*, 20, 3985-3990.
12	Yoshida, H., Kuriyama, I., Sakamoto, Y.T., Mizushina, Y. (2012) Profiles of lipid components, fatty acid compositions and triacylglycerol molecular species in the lipids from rice beans. Food Science and Technology Research*, 18, 219-226.
13	Takao, Y., Kuriyama, I., Yamada, T., Mizoguchi, H., Yoshida, H., Mizushina, Y. (2012) Antifungal properties of Japanese cedar essential oil from waste wood chips made from used sake barrels. Molecular Medicine Reports*, 5, 1163-1168.
14	Myobatake, Y., Takeuchi, T., Kuramochi, K., Kuriyama, I., Ishido, T., Hirano, K., Sugawara, F., Yoshida, H., Mizushina, Y. (2012) Pinophilins A and B, inhibitors of mammalian A-, B- and Y-families of DNA polymerases and human cancer cell proliferation. Journal of Natural Products*, 75, 135-141.
15	Mizuno, T., Kuriyama, I., Takemura, M., Sakaguchi, K., Sugawara, F., Yoshida, H., Mizushina, Y. (2012) Effect of a specific mammalian DNA polymerase α inhibitor, dehydroaltenusin, on DNA replication in cultured cells. DNA Replication and Mutation*, 4, 67-90.
16	Mizushina, Y., Takahashi, Y., Sato, Y., Yamaguchi, Y., Takeuchi, T., Kuriyama, I., Sugawara, F., Yoshida, H. (2012) Inhibition of DNA polymerase λ by glucosyl compounds from soybean (Glycine max L.) and their associated inflammatory activity. Food Chemistry*, 132, 2046-2053.

1	Mizushina, Y., Nishida, M., Azuma, T., Yoshida, M. (2011) Inhibition of DNA polymerase λ, a DNA repair enzyme, and anti-inflammation: chemical knocked out analysis for DNA polymerase λ by curcumin derivatives. DNA Repair and Human Health, 31, 777-792.
2	Mizushina, Y., Maeda, N., Kuriyama, I., Yoshida, H. (2011) Dehydroaltenusin is a specific inhibitor of mammalian DNA polymerase α. Expert Opinion on Investigational Drugs*, 20, 1523-1534.
3	Aoganghua, A., Nishiumi, S., Kobayashi, K., Nishida, M., Kuramochi, K., Tsubaki, K., Hirai, M., Tanaka, S., Azuma, T., Yoshida, H., Mizushina, Y., Yoshida, M. (2011) Inhibitory effects of vitamin K3 derivatives on DNA polymerase and inflammatory activities. International Journal of Molecular Medicine, 28, 937-945.
4	Maruo, S., Kuriyama, I., Kuramochi, K., Tsubaki, K., Yoshida, H., Mizushina, Y. (2011) Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. Bioorganic and Medicinal Chemistry, 19, 5803-5812.
5	Mizushina, Y., Takeuchi, T., Kuriyama, I., Takahashi, Y., Maezawa, S., Matsumoto, T., Koiwai, O., Sugawara, F., Yoshida, H. (2011) DNA polymerase β specific inhibitors, a loliolide derivative and pubinernoid A, isolated from the brown algae Laminaria sp.. Letters in Drug Design and Discovery*, 8, 671-677.
6	Takemura, M., Kazama, T., Sakuma, K., Mizushina, Y., Oshima, T (2011) Growth inhibition and chromosomal instability of cultured marsupial (opossum) cells after treatment with DNA polymerase α inhibitor. Bioscience Biotechnology and Biochemistry*, 75, 1349-1353.
7	Kuramochi, K., Sunoki, T., Tsubaki, K., Mizushina, Y., Sakaguchi, K., Sugawara, F., Ikekita, M., Kobayashi, S. (2011) Transformation of thiols to disulfides by epolactaene and its derivatives. Bioorganic and Medicinal Chemistry*, 19, 4162-4172.
8	Yoshida, H., Tanigawa, T., Yoshida, N., Kuriyama, I., Tomiyama, Y., Mizushina, Y. (2011) Lipid components, fatty acid distributions of triacylglycerols and phospholipids in rice brans. Food Chemistry*, 129, 479-484.
9	Mizushina, Y., Saito, A., Horikawa, K., Nakajima, N., Tanaka, A., Yoshida, H., Matsubara, K. (2011) Acylated catechin derivatives: inhibitors of DNA polymerase and angiogenesis. Frontiers in Bioscience*, E3, 1337-1348.
10	Yoshida, H., Tanigawa, T., Kuriyama, I., Yoshida, N., Tomiyama, Y., Mizushina, Y. (2011) Variation in fatty acid distribution of different acyl lipids in rice (Oryza sativa L.) brans. Nutrients*, 3, 505-514.
11	Yim, M.J., Hosokawa, M., Mizushina, Y., Yoshida, H., Saito, Y., Miyashita, K. (2011) Suppressive effects of amarouciaxanthin A on 3T3-L1 adipocyte differentiation through down-regulation of PPARγ and C/EBPα mRNA expression. Journal of Agricultural and Food Chemistry*, 59, 1646-1652.
12	Mizushina, Y., Maeda, J., Irino, Y., Nishida, M., Nishiumi, S., Kondo, Y., Nishio, K., Kuramochi, K., Tsubaki, K., Kuriyama, I., Azuma, T., Yoshida, H., Yoshida, M. (2011) Effects of intermediates between vitamins K2 and K3 on mammalian DNA polymerase inhibition and anti-inflammatory activity. International Journal of Molecular Sciences, 12, 1115-1132.
13	Kuramochi, K., Kuriyama, I., Mori, M., Kamisuki, S., Takahashi, S., Tsubaki, K., Sugawara, F., Sakaguchi, K., Yoshida, H., Mizushina, Y. (2011) Syntheses of dehydroaltenusin, a selective inhibitor of mammalian DNA polymerase α. Current Organic Synthesis*, 8, 134-144.
14	Yoshida, H., Yoshida, N., Tomiyama, Y., Mizushina, Y. (2011) Composition and regiodistribution of fatty acids in triacylglycerols and phospholipids from red and black rices. Cereal Chemistry*, 88, 31-35.
15	Kobayashi, K., Nishiumi, S., Nishida, M., Hirai, M., Azuma, T., Yoshida, H., Mizushina, Y., Yoshida, M. (2011) Effects of quinone derivatives, such as 1,4-naphthoquinone, on DNA polymerase inhibition and anti-inflammatory action. Medicinal Chemistry, 7, 37-44.
16	Maeda, N., Matsubara, K., Yoshida, H., Mizushina, Y. (2011) Anti-cancer effect of spinach glycoglycerolipids as angiogenesis inhibitors based on the selective inhibition of DNA polymerase activity. Mini-Reviews in Medicinal Chemistry*, 11, 32-38.
17	Okusada, K., Nakamoto, K., Nishida, M., Hamabe, W.F., Kamiya, K., Mizushina, Y., Satake, T., Tokuyama, S. (2011) The antinociceptive and anti-inflammatory action of the CHCl3-soluble phase and its main active component, damnacanthal, isolated from the root of Morinda citrifolia. Biological & Pharmaceutical Bulletin*, 34, 103-107.

1	Kuriyama, I., Miyazaki, A., Tsuda, Y., Yokoi, T., Okada, Y., Takeuchi, T., Sugawara, F., Yoshida, H., Mizushina, Y. (2010) Inhibitory effect of somatostatin peptide analogues on DNA polymerase activity and human cancer cell proliferation. Anticancer Research*, 30, 4841-4849.
2	Yoshida, H., Tomiyama, Y., Mizushina, Y. (2010) Tocopherol distributions and triacylglycerol molecular species in broad beans (Vicia Faba). Food Science and Technology Research*, 16, 409-416.
3	Horie, S., Okuda, C., Yamashita, T., Watanabe, K., Yamaguchi, Y., Takeuchi, T., Sugawara, F., Yoshida, H., Mizushina, Y. (2010) β-Sitosteryl (6’-O-linoleoyl)-glucoside of soybean (Glycine max L.) crude extract inhibits Y-family DNA polymerases. Journal of Oleo Science*, 59, 621-630.
4	Amalia, H., Sasaki, R., Suzuki, Y., Demizu, Y., Bito, T., Nishimura, H., Okamoto, Y., Yoshida, K., Miyawaki, D., Kawabe, T., Mizushina, Y., Sugimura, K. (2010) Vitamin K2 derived compounds induce growth inhibition in radioresistant cancer cells. Kobe Journal of Medical Sciences*, 56, E38-E49.
5	Maeda, J., Nishida, M., Takikawa, H., Yoshida, H., Azuma, T., Yoshida, M., Mizushina, Y. (2010) Inhibitory effects of sulfobacin B on DNA polymerase and inflammation. International Journal of Molecular Medicine, 26, 751-758.
6	Harada, S., Fujita-Hamabe, W., Kamiya, K., Mizushina, Y., Satake, T., Tokuyama, S. (2010) Morinda citrifolia fruit juice prevents ischemic neuronal damage through suppression of the development of post-ischemic glucose intolerance. Journal of Natural Medicines*, 64, 468-473.
7	Mizushina, Y., Zhang, J., Pugliese, A., Kim, S.H., Lü, J. (2010) Anti-cancer gallotannin penta-O-galloyl-beta-D-glucose is a nanomolar inhibitor of select mammalian DNA polymerases. Biochemical Pharmacology, 80, 1125-1132.
8	Mizushina, Y., Nishimura, N., Takenaka, Y., Takeuchi, T., Sugawara, F., Yoshida, H., Tanahashi, T. (2010) Inhibitory effects of docosyl p-coumarate on DNA topoisomerase activity and human cancer cell growth. International Journal of Oncology*, 37, 933-1000.
9	Kayashima, T., Mori, M., Mizutani, R., Nishino, K., Kuramochi, K., Tsubaki, K., Yoshida, H., Mizushina, Y., Matsubara, K. (2010) Synthesis and biological evaluation of vitamin K derivatives as angiogenesis inhibitor. Bioorganic and Medicinal Chemistry*, 18, 6305-6309.
10	Horie, S., Okuda, C., Yamashida, T., Watanabe, K., Kuramochi, K., Hosokawa, M., Takeuchi, T., Kakuda, M., Miyashida, K., Sugawara, F., Yoshida, H., Mizushina, Y. (2010) Purified canola lutein selectively inhibits specific isoforms of mammalian DNA polymerases and reduces inflammatory response. Lipids*, 45, 713-721.
11	Hirano, K., Yoshida, Y., Ishidoh, T., Wada, Y., Moriya, N., Yamazaki, N., Mizushina, Y., Baba, Y., Ishikawa, M. (2010) Consecutive incorporation of fluorophore-labelled nucleotides by mammalian DNA polymerase β. Analytical Biochemistry*, 405, 160-167.
12	Ishimaru, C., Takeuchi, T., Sugawara, F., Yoshida, H., Mizushina, Y. (2010) Inhibitory effects of diacylglyceride phospholipids on DNA polymerase and topoisomerase activities, and human cancer cell growth. Medicinal Chemistry*, 6, 114-122.
13	Mizushina, Y., Sakaguchi, K., Sugawara, F., Yoshida, H. (2010) Inhibitory mechanism of longer chain fatty acids on mammalian DNA polymerase beta activity. Handbook of Nutritional Biochemistry: Genomics, Metabolomics and Food Supply*, 445-463.
14	Yoshida, H., Yoshida, N., Tomiyama, Y., Mizushina, Y. (2010) Fatty acid characteristics of triacylglycerols and phospholipids of azuki beans (Vigna angularis). Food Science and Technology Research*, 16, 209-214.
15	Yoshida, H., Tomiyama, Y., Mizushina, Y. (2010) Lipids components, fatty acids and triacylglycerol molecular species of black and red rices. Food Chemistry*, 123, 210-215.
16	Yamaguchi, Y., Manita, D., Takeuchi, T., Kuramochi, K., Kuriyama, I., Sugawara, F., Yoshida, H., Mizushina, Y. (2010) Novel terpenoids, trichoderonic acids A and B isolated from Trichoderma virens, are selective inhibitors of family X DNA polymerases. Bioscience Biotechnology and Biochemistry*, 74, 793-801.
17	Tanaka, S., Nishiumi, S., Nishida, M., Mizushina, Y., Kobayashi, K., Masuda, A., Fujita, T., Morita, Y., Mizuno, S., Kutsumi, H., T.Azuma, T., Yoshida, M. (2010) Vitamin K3 attenuates lipopolysaccharide-induced acute lung injury through inhibition of nuclear factor-κB activation. Clinical and Experimental Immunology*, 160, 283-292.
18	Nishida, M., Nishiumi, S., Mizushina, Y., Fujishima, Y., Yamamoto, K., Masuda, A., Mizuno, S., Fujita, T., Morita, Y., Kutsumi, H., Yoshida, H., Azuma, T., Yoshida, M. (2010) Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-κB activation. International Journal of Molecular Medicine*, 25, 761-767.
19	Yonezawa, Y.K., Sasaki, R., Suzuki, Y., Matsui, Y., Hada, T., Uryu, K., Sugimura, K., Yoshida, H., Mizushina, Y. (2010) Enhancement of human cancer cell radiosensitivity by conjugated eicosapentaenoic acid - a mammalian DNA polymerase inhibitor. International Journal of Oncology*, 36, 577-584.
20	Yoshida, H., Tomiyama, Y., Yoshida, N., Shibata, K., Mizushina, Y. (2010) Regiospecific profiles of fatty acids in triacylglycerols and phospholipids from adzuki beans (Vigna angularis). Nutrients*, 2, 49-59.
21	Kamiya, K., Hamabe, W., Tokuyama, S., Hirano, K., Satake, T., Yonezawa, Y.K., Yoshida, H., Mizushina, Y. (2010) Inhibitory effect of anthraquinones isolated from the root of Noni (Morinda citrifolia) on animal A, B and Y families of DNA polymerases and human cancer cell proliferation. Food Chemistry*, 118, 725-730.
22	Matsui Y., Takeuchi, T., Yonezawa, Y.K., Takemura, M., Sugawara, F., Yoshida, H., Mizushina, Y. (2010) The relationship between the molecular structure of natural acetogenins and their inhibitory activities which affect DNA polymerase, DNA topoisomerase and human cancer cell growth. Experimental and Therapeutic Medicine*, 1, 19-26.
23	Maeda, N., Yoshida, H., Mizushina, Y. (2010) Spinach and health: Anti-cancer effect. Bioactive Foods in Promoting Health: Fruits and Vegetables*, Chapter 26, 393-405.