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Kobe Gakuin University > Faculty of Nutrition > Laboratory of Physiology > Japanese-European Kobe Symposium on Thrombosis 2000
JAPNESE-EUROPEAN KOBE SYMPOSIUM ON THROMBOSIS
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JEKST
Date: 6-7th November 2000
Venue: Kobe Gakuin University, Kobe, Japan
Theme: Novel Technologies in Diagnosis and Research on Thrombosis
 
Organising Committee (alphabetical order)
Honorary President
S. Okamoto MD PhD
Professor Emeritus Kobe University
Honorary Vice-President
U. Okamoto MD PhD
Professor Emeritus Kobe Gakuin University
President
T. Ueda MD PhD
Dean of Faculty of Nutrition, Kobe Gakuin University
Chairman of Organising Committee
J. Yamamoto PhD
Faculty of Nutrition, Kobe Gakuin University
Secretary General
T. Yamashita PhD
Faculty of Nutrition, Kobe Gakuin University
Members (in alphabetical orders)
Y. Fukumori PhD
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe
 
H. Ikarugi
Laboratory of Exercise Physiology, Kobe University of Commerce, Kobe
 
N. Kajiwara PhD
Kobe Women's College, Kobe
 
Y. Okada PhD
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe
 
T. Okuda PhD
Osaka Kyoiku University, Osaka
 
Y. Sasaki PhD
Faculty of Nutrition, Kobe Gakuin University, Kobe
 
T. Taka
Faculty of Nutrition, Kobe Gakuin University, Kobe
 
N. Totani PhD
Faculty of Nutrition, Kobe Gakuin University, Kobe
 
Y. Tsuda PhD
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe
 
S. Watanabe PhD
Division of Basic Medical Science, Kobe City College of Nursing, Kobe
Scientific Programme Committee (in alphabetical orders)
Chairman
J. Yamamoto PhD
Faculty of Nutrition, Kobe Gakuin University, Kobe
Members (in alphabetical orders)
T. Ariga PhD
Nihon University College of Bioresource Sciences, Tokyo
 
Y. Fukumori PhD
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe
 
O. Matsuo MD PhD
Kinki University School of Medicine, Osaka
 
Y. Okada PhD
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe
 
M. Sato PhD
Department of Engineering, Tohoku University, Sendai
 
J. Seki PhD
Department of Bioengineering, National Cardiovascular Center Research Institute, Osaka
 
K. Umemura MD PhD
Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu
 
A. Yoshioka MD PhD
Department of Pediatrics, Nara Medical College, Nara
International Scientific Advisory Board (in alphabetical orders)
J.C. Giddings PhD
Department of Haematology, University of Wales College of Medicine, Cardiff
P. Gorog PhD DSc
Montrose Diagnostics Ltd., Formerly William Harvey Research Institute, London
S. Heptinstall PhD
Cardiovascular Medicine, School of Medical and Surgical Sciences, University of Nottingham, Nottingham
I.B. Kovacs MD PhD
Thrombosis Clinic, London Medical Centre, Formerly St. Bartholomew’s Hospital Medical School, London
M.M.A. Kratzer MD PhD
Institute of Transfusion Medicine and Haemostaseology, University Hospital, Marburg
E.G.D. Tuddenham MD PhD
Imperial College School of Medicine, Hammersmith Hospital, London
Meeting Secretariat
T. Yamashita PhD, Laboratory of Physiology, Faculty of Nutrition, Kobe Gakuin University,
Arise, Ikawadani-cho, Nishi-ku, Kobe, Japan
Tel: +81-78-974-1551, ext. 3251; Fax: +81-78-974-5689
Patrons
Kobe Gakuin University, Faculty of Nutrition Kobe Gakuin University, Kobe Gakuin University High Technology Center, Hyogo International Association, Kobe International Sightseeing Convention Association
Contributors
The Osaka Pharmaceutical Manufacturers Association
The Pharmaceutical Manufacturers' Association of Tokyo
Nakauchi Convention Foundation
Uehara Memorial Foundation
 
PROGRAMME
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Theme: Novel Technologies in Diagnosis and Research on Thrombosis
Date: November 6th 2000 (Monday)
9:25
Opening remarks
Junichiro Yamamoto
9:30
(Chairman: Junichiro Yamamoto)
Plenary lecture
Iren B. Kovacs
Thrombosis Clinic, London Medical Centre, Formerly St. Bartholomew's Hospital Medical School, London
Modelling human thrombosis: from animal experiments to global in vitro tests
10:00
(Chairman: John C. Giddings)

Oral presentation: Animal models of microthrombosis
1) Yasuto Sasaki1,2, Takanori Noguchi1, Hiroaki Ono1, Junji Seki3, John C. Giddings4, Junichiro Yamamoto1,2
1Laboratory of Physiology, Faculty of Nutrition, Kobe Gakuin University, Kobe, 2High Technology Research Centre, Kobe Gakuin University, Kobe, 3Department of Biomedical Engineering, National Cardiovascular Centre Research Institute, Osaka, 4Department of Haematology, University of Wales College of Medicine, Cardiff
He-Ne laser-induced thrombosis model in pial vessels of SHRSP

2) Tsutomu Yamashita1,2, Tomomi Taka1,2, Masaru Hashimoto1,2, Rie Nojima1, Yoshio Ohta3, John C. Giddings4, Junji Seki5, Junichiro Yamamoto1,2
1Laboratory of Physiology, Faculty of Nutrition, Kobe Gakuin University, Kobe, 2High Technology Research Centre, Kobe Gakuin University, Kobe, 3Department of Pathology and Laboratory Medicine, Nara Hospital, Kinki University School of Medicine, Nara, 4Department of Haematology, University of Wales College of Medicine, Cardiff, 5Department of Biomedical Engineering, National Cardiovascular Centre Research Institute, Osaka
In vivo and in vitro platelet thrombus formation in microvessels of stroke-prone spontaneously hypertensive rats (SHRSP)

10:30
(Chairman: Masaaki Sato)
Plenary lecture
Kazuo Umemura, Yasuhiro Suzuki
Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu
Photothrombotic occlusion model of the middle cerebral artery
11:00
(Chairman: Shigeki Miyata, Taiichiro Seki)
Oral presentation: Animal models of arterial/ venous thrombosis
1) Yasuhiro Suzuki1, Hiroyuki Takamatsu1,2, Kazuo Umemura1
1Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, 2The Medical and Pharmacological Research Centre Foundation, Ishikawa
The photochemically-induced thrombotic middle cerebral artery occlusion model in rat: comparison with the thermocoagulated occlusion model

2) Yoshimi Imura
Pharmacology Research Laboratories II, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., Osaka
Evaluation of antithrombotic agents using a venous thrombosis model

12:00
(Chairman: Eizou Kakishita)
Mitsubishi-Tokyo Pharmaceuticals Inc. Luncheon Seminar:
Argatroban: A small-molecule, direct thrombin inhibitor - up to date

1) Takefumi Matsuo
Hyogo Prefectural Awaji Hospital
Argatoroban and heparin - intolerant patients requiring extracorporeal circulation

2) Tadanori Kawada
Department of Surgery, Showa University School of Medicine, Tokyo
Clinical application of argatroban as an alternative for extracorporeal circulation

14:00
(Chairman: Michael M. A. Kratzer)
Plenary lecture
Peter Gorog
Montrose Diagnostics Ltd., Formerly William Harvey Research Institute, London
Assessment of platelet reactivity by shear as sole agonist
14:30
(Chairman: Junji Seki)
Oral presentation: Shear-induced platelet aggregation
1) Hideo Ikarugi1, Tomomi Taka2,3, Shoko Nakajima2, Takanori Noguchi2, Takashi Ueda3,4, Sadahiro Watanabe5, Yasuto Sasaki2,3, Junji Seki6, Junichiro Yamamoto2,3
1Laboratory of Exercise Physiology, Kobe University of Commerce, Kobe, 2Laboratory of Physiology, Faculty of Nutrition, Kobe Gakuin University, Kobe, 3High Technology Research Centre, Kobe Gakuin University, Kobe, 4Laboratory of Nutritional Physiology, Faculty of Nutrition, Kobe Gakuin University, Kobe, 5Division of Basic Medical Science, Kobe City College of Nursing, Kobe, 6Department of Biomedical Engineering, National Cardiovascular Centre Research Institute, Osaka Effects of acute exercise and catecholamines on thrombosis
14:45
(Chairman: Peter Gorog)
Plenary lecture
Michael M. A. Kratzer, Sascha Bade, Volker Kretschmer
Institute of Transfusion Medicine and Haemostaseology, University Hospital, Marburg
Measurement of primary hemostasis ex vivo
15:15
(Chairman: Norio Tanahashi)
Oral presentation: Shear-induced platelet aggregation
1) Volker Kretschmer, Sascha Bade, Monika Weippert-Kretschmer, Michael M. A. Kratzer
Institute of Transfusion Medicine and Haemostaseology, University Hospital, Marburg
First results with improved PFA-100 test
15:30
(Chairman: Mitsuhiko Sugimoto, Noriyuki Kataoka)
Oral presentation: Blood rheology
1) Yuji Kikuchi
Food Engineering Division, National Food Research Institute, Tsukuba
Measurement of blood rheology using microfabricated capillaries

2) Junji Seki
Department of Biomedical Engineering, National Cardiovascular Centre Research Institute, Osaka
Blood flow measurements in microvessels by laser-doppler method

 
(Break)
16:30
(Chairman: Stanley Heptinstall)
Plenary lecture
Mitsuhiko Sugimoto
Department of Pediatrics, Nara Medical University, Nara
Shear-dependent functions of adhesive proteins in platelet thrombus formation under flow
17:00
(Chairman: Shigeru Ueshima)
Oral presentation: Platelet reaction under flow
1) Shigeki Miyata1, Mitsuhiko Sugimoto2
1Division of Blood Transfusion Medicine, National Cardiovascular Centre, Osaka, 2Department of Pediatrics, Nara Medical University, Nara
Structure and function of von Willebrand factor A1 domain initiating platelet thrombus formation
17:30
Get-together Party
November 7th (Tuesday)
9:30
(Chairman: Kazuo Umemura)
Plenary lecture
Osamu Matsuo
Department of Physiology, Kinki University School of Medicine, Osakasayama
Thrombolytic enzymes
10:00
(Chairman: Yoshimi Imura)
Oral presentation: Thrombolytic enzymes
1) Shigeru Ueshima, Osamu Matsuo
Department of Physiology, Kinki University School of Medicine, Osakasayama
Endothelial cells and fibrinolytic system
10:15
(Chairman: Yuji Kikuchi)

Plenary lecture
Masaaki Sato
Biomechanics Laboratory, Graduate School of Mechanical Engineering, Tohoku University, Sendai
Endothelial cells under flow - Regulation of cellular activity by mechanical stimuli -

10:45
(Chairman: Yasuhiro Suzuki, Nagao Totani)
Oral presentation: Endothelial cells and thrombosis
1)Noriyuki Kataoka1, Kanso Iwaki2, Seiichi Mochizuki1, Yasuo Ogasawara1, Katsuhiko Tsujioka3, Fumihiko Kajiya1,4
1Department of Medical Engineering, Kawasaki Medical School, Kurashiki, 2Hayashibara Biochemical Laboratories, Inc., Okayama, 3Department of Physiology, Kawasaki Medical School, Kurashiki, 42nd Department of Physiology, Okayama University Medical School, Okayama
Changes in endothelial function and micro-structures inside endothelial cells induced by interaction between monocyte and endothelial cells

2)Norio Tanahashi, Yasuo Fukuuchi, Minoru Tomita, Yutaka Tomita, Kouzi Inoue, Hideki Satoh, Takahito Abe
Department of Neurology, School of Medicine, Keio University,Tokyo
Role of platelet glycoprotein IIb/IIIa in platelet adhesion to human brain microvascular endothelial cells in vitro. Observation with video-enhanced contrast microscopy

11:15
(Chairman: Akira Yoshioka)
Plenary lecture
John C. Giddings
The Arthur Bloom Haemophilia and Haemostasis Centre, Department of Haematology,
University of Wales College of Medicine, Cardiff
Interactions of blood cells under flow
 
(Lunch)
14:00
(Chairman: Edward G. D. Tuddenham)
Plenary lecture
Stanley Heptinstall
Cardiovascular Medicine, School of Medical and Surgical Sciences, University of Nottingham, Nottingham
Antiplatelet agents and thrombosis
14:30
(Chairman: Yoshio Okada, Yasuto Sasaki)
Oral presentation: Antiplatelet agent
1) Yuko Tsuda1,2, Tomomi Taka2,3, Yasuo Konishi4, Jacek Slon-Usakiewicz4, Viacheslav Medvedkin4, Junji Seki5, Junichiro Yamamoto2,3, Yoshio Okada1,2
1Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, 2High Technology Research Centre, Kobe Gakuin University, Kobe, 3Faculty of Nutrition, Kobe Gakuin University, Kobe, 4Biotechnology Research Institute, National Research Council Canada, Montreal, 5Department of Biomedical Engineering, National Cardiovascular Centre Research Institute, Osaka
Design of bifunctional thrombin inhibitors and their effect on shear-induced platelet function and dynamic coagulation

2) Akiko Hijikata-Okunomiya1, Keiko Wanaka2, Shosuke Okamoto2
1Faculty of Health Science, Kobe University School of Medicine, Kobe, 2Kobe Research Projects on Thrombosis and Haemostasis, Kobe Argatroban and its derivatives

3) Tsuyoshi Hara1, Toshio Fukuda1, Yumiko Hirokawa1, Takayasu Nagahara1, Satoshi Kunitada2
1New Product Research Laboratories II, Daiichi Pharmaceutical Co. Ltd., Tokyo, 2Global Medical Planning Department, Daiichi Pharmaceutical Co. Ltd., Tokyo
A newly synthetic, direct and selective factor Xa inhibitor DX-9065a; its anti-Xa, anticoagulant and antithrombotic activities

15:15
(Chairman: Toyohiko Ariga, Naemi Kajiwara)
Oral presentation: Diet and thrombosis
1) Taiichiro Seki1, Toyohiko Ariga1, Junichiro Yamamoto2,3
1Laboratory of Nutrition and Physiology, Nihon University College of Bioresource Sciences, Kanagawa, 2Laboratory of Physiology, Faculty of Nutrition, Kobe Gakuin University, Kobe, 3High Technology Research Centre, Kobe Gakuin University, Kobe
Anti-thrombotic effect of garlic

2) Junichiro Yamamoto1,2, Tomomi Taka1,2, Yoshinobu Ijiri1,2, Masaru Hashimoto1,2, Kazuya Kitamori1,2, Kaori Yamada1,2, Tsutomu Yamashita1,2, Yasuto Sasaki1,2, Kazuhiro Oiwa3, Junji Seki4, Hiroyuki Suganuma5, Takahiro Inakuma5
1Laboratory of Physiology, Faculty of Nutrition, Kobe Gakuin University, Kobe, 2High Technology Research Centre, Kobe Gakuin University, Kobe, 3Communications Research Laboratory, Kansai Advanced Research Centre, Kobe, 4Department of Biomedical Engineering, National Cardiovascular Centre Research Institute, Osaka, 5Food Product Development Division, Kagome Co. Ltd., Nasu
Tomato: a natural antithrombotic potential

3)Takanori Noguchi1, Katsumi Ikeda1, Yasuto Sasaki2,3, Etsuko Yamamoto2,3, Tsutomu Yamashita2,3, Junichiro Yamamoto2,3, Hiroshi Hara4, Hanzo Kakuta4, Yasuo Nara5, Junji Seki6, Yukio Yamori1
1Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, 2Laboratory of Physiology, Faculty of Nutrition, Kobe Gakuin University, Kobe, 3High Technology Research Centre, Kobe Gakuin University, Kobe, 4Fujimi-Youhou-En, Saitama, 5Graduate School of Integrated Science of Art, University of East Asia, Yamaguchi, 6Department of Biomedical Engineering, National Cardiovascular Centre Research Institute, Osaka
Effects of sesamin and vitamin E on cerebral thrombosis and microcirculation in SHRSP

16:00
(Chairman: Iren B. Kovacs)
Plenary lecture
Edward G. D. Tuddenham1, Colin Davidson1, Gregory Elgar2, John H. McVey1
1Haemostasis Research Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, 2HGMP Resource Centre, Genome Campus, Cambridge
The evolution of vertebrate coagulation
15:30
(Chairman: Mitsuhiko Sugimoto, Noriyuki Kataoka)
Oral presentation: Blood rheology
1) Yuji Kikuchi
Food Engineering Division, National Food Research Institute, Tsukuba
Measurement of blood rheology using microfabricated capillaries

2) Junji Seki
Department of Biomedical Engineering, National Cardiovascular Centre Research Institute, Osaka
Blood flow measurements in microvessels by laser-doppler method

16:00
(Chairman: Iren B. Kovacs)
Plenary lecture Edward G. D. Tuddenham1, Colin Davidson1, Gregory Elgar2, John H. McVey1
1Haemostasis Research Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, 2HGMP Resource Centre, Genome Campus, Cambridge
The evolution of vertebrate coagulation
16:30
Closing remarks
Masaaki Sato
* Plenary lecture: 30 minutes including 5 minutes Discussion; Oral presentation: 15 minutes including 3 minutes Discussion
November 8th (Wednesday)
Optional one day coach tour to Kyoto
 
 
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